Endocrine Abstracts

Up till now, altered balance of Th1 and Th2 immune cells has been postulated to play an important role in the pathogenesis of autoimmune thyroid diseases (AITD). However, recent studies on thyroid diseases suggest a new role for Th17 (T helper 17) cells that have been classified as a new lineage, distinct from Th1, Th2 and Treg cells. Despite wide interest, role of Th17 cells in the pathogenesis of inflammatory and autoimmune diseases is still debated. Th17 cells are involved ...

Autoimmune thyroid disease (AITD) is the most common organ-specific autoimmune disorder. Genetic background, environmental and endogenous factors are play important roles in determining the activation of immune cells or the efficacy of the immunoregulatory pathways. In recent years underlined the immunosuppressive role of T lymphocytes with expression of CD4+CD25+ (Tregs) in regulation mechanisms of peripheral immune tolerance.The aim of the study was to...

Introduction: FOXP3 is a critical determinant of T regulatory cells (Tregs) development and function. Treg cells play a crucial role in modulating potentially self-reactive clones, and dysfunction of this cell type contributes to autoimmune disease such as Graves’ disease (GD) and Hashimoto’s thyroiditis (HT). The aim of our study was to estimate the association of three polymorphism of FOXP3 gene with the predisposition to GD and HT in Polish population.<p class...